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ABBREVIATIONS: CAP = College of American Pathologists; [ INDEX TERMS: enzyme deficiency; Glucose-6-phosphate dehydrogenase; hemolytic anemia; medical decision chart; Roche Cobas Mira Plus.
Microbial peroxidase associated with urinary tract infection may cause a false-positive reaction.
Levels of ascorbic acid normally found in urine do not interfere with this test.
G6PD deficiency is the most widely distributed enzyme defect of erythrocytes in humans, therefore, it is important to screen all service members for the enzyme deficiency before they are prophylaxed in preparation for deployment.
(4) This potential for drug induced hemolytic complications demands screening and for that reason, the analytical procedures for assessing G6PD concentrations must be rigorously validated to ensure the best quantitative determinations.
A] = allowable error; G6PD = Glucose-6-phosphate dehydrogenase; MDC = medical decision chart; MDL = medical decision level; NADP = nicotinamide adenine dinucleotide phosphate; [ Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme of clinical significance to the Armed Services.
The ability to determine accurate erythrocyte concentrations of G6PD is imperative for the prophylaxis and treatment of service members against a variety of opportunistic hemolytic infectious diseases, such as malaria, which might be encountered during deployment.Our initial GWAS revealed the presence of two single nucleotide polymorphisms (SNPs) (ASGA0069038 and ALGA0084612) for the hemoglobin concentration trait (HGB) in the 2.48 Mb region of SSC15.From this target region, GYPC was selected as a promising gene that associated with serum HGB traits in pigs.Injury to skeletal or cardiac muscle results in the release of myoglobin, which also is detected by this assay.Conditions associated with myoglobinuria include hereditary myoglobinuria, phosphorylase deficiency, sporadic myoglobinuria, exertional myoglobinuria in untrained individuals, crush syndrome, myocardial infarction, myoglobinuria of progressive muscle disease, and heat injury.Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.